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产品介绍 当前位置:首页 > 产品介绍 > 颅脑脊髓撞击

类型: 颅脑脊髓撞击

名称:大小鼠精密颅脑损伤撞击器

PinPoint™ Precision Cortical Impactor™

型号:PCI-3000-1

  • 产品介绍
  • 产品特点
  • 产品参数
  • 产品应用
  • 文献参考

PinPoint™是一款用于基础医学研究的颅脑损伤撞击器,主要用于大小鼠动物模型身上的脑部损伤和脊髓损伤。该产品具有控制精准、功能强大和灵活精确、极好的有效性和重复性。
 
系统结构:
PinPoint™是一款用于基础医学研究的颅脑损伤撞击器,主要用于大小鼠动物模型身上的脑部损伤和脊髓损伤。该产品具有控制精准、功能强大和灵活精确、极好的有效性和重复性。
 
PCI-3000-1适用于大小鼠   
1.   使用一个标准的动物脑立体定位仪的一个操作臂来安装固定撞击器的驱动电机。
2.   驱动电机通过一个安装适配器来安装到动物脑立体定位仪上。
3.   最简单的结构,最简洁的组成。
4.   源自PinPoint最初的设计。
 
结构方式1系统组成:
1.   驱动电机
2.   驱动电机安装适配器
3.   撞击头
4.   控制单元
5.   软件
(不包含定位仪)

 

撞击程序:
整个撞击过程是一个容易操作的程序。手术暴露颅脑或脊髓之后:
1.   放置直线型的电机
2.   放低操纵臂,直到撞击头接触目标位置
3.   收回操纵臂到开始位置
4.   初始化撞击
 
 1552893636694662.jpg 

撞击示意图

 

界面化的软件:
PinPoint使用GUI图形用户界面软件,可安装在一个标准的PC机上或笔记本电脑上。它的点击式的功能允许使用者:
1.  调节撞击速度、深度和保持时间
2.  控制臂的垂直运动
3.  发动撞击
4.  记录主要的数据
5.  浏览、保存和输出数据

 

No Motor&Ram Diagram.jpg

 

 

 

 

 

 

 

PinPoint™ 使用GUI图形用户友好界面软件,易于操作,直观性好,可安装在一个标准的PC机上或笔记本电脑上,点击式应用功能允许使用者:可自由的调节撞击速度、深度和撞击后的保持时间、控制臂的垂直运动、启动撞击,软件自动记录主要的数据,可浏览、保存和输出数据,撞击结果还可以以图形形式表现,确保优良的品质,操作系统平台支持Win95,2000,XP等。

 


产品配置

系统的组成元件是PinPoint的强大功能和多功能性背后的驱动力,尤其重要的是驱动电动机、撞击头、控制单元、和驱动电机安装适配器、大鼠脊髓适配器或小鼠脊髓适配器、U型脑立体定位仪基座(可选)、标准脑立体定位仪(可选)

 

1.  微处理器控制;
2.  完整的报警接触传感器,当撞击头接触到头部的时候,驱动电机和撞击杆自动建立参考点;

3.  传感器采用了视觉和听觉的指示器来提醒使用者接触的发生;

4.  听觉指示器可选操作,可以按下位于控制单元前面板上的电源开关来关闭它,同时带有音量调节旋钮;

5.  简单易用的GUI图形用户友好界面软件 ;

6. 撞击速度可调范围:0.1-4m/s ;
7. 撞击深度可调范围:0-15mm;
8. 撞击后的保持时间可调范围:0-5000(毫秒级)

9.  配备有七种撞击头尺寸(1 到 5mm范围内:1、1.5、2、2.5、3、4、5 mm);

10. 软件自动记录主要的数据,可浏览、保存和输出数据,撞击结果还可以以图形形式表现;

11. 操作系统平台支持Win95,2000,XP等。

12. 可360度范围旋转;

13. 多型号配置选择;

 

主要用于大小鼠动物模型的颅脑损伤和脊髓损伤的撞击。

 

目前典型用户:
北京市神经科学研究所、北京天坛医院、北京工业大学、上海交通大学医学院、上海交通大学附属仁济医院、浙江大学医学院附属第二医院、上海市第六人民医院、上海市精神卫生中心、连云港市东方医院、江苏省人民医院脑外科、华南理工大学、广东省中医院、重庆市第七人民医院、昆明医科大学第三附属医院、中国医科大学、福建医科大学附属第一医院......

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BACKGROUND Mild hypothermia is wildly used in clinicaltreatment of traumatic brain injury (TBI). However, the effect of mildhypothermia on endoplasmic reticulum (ER) stress-induced apoptosis after… (More)

 

Bone MarrowDerived Extracellular Vesicles Activate Osteoclast Differentiation in TraumaticBrain Injury Induced Bone Loss Quante Singleton, Kumar Vaibhav, +13 authors Sadanand Fulzele  Cells  2019

Traumatic brain injury (TBI) is a major source ofworldwide morbidity and mortality. Patients suffering from TBI exhibit a highersusceptibility to bone loss and an increased rate of bone fractures;… (More)

 

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AControlled Impact of Optic Nerve as a New Model of TraumaticOptic Neuropathy in Mouse  Ahmed Samir Ibrahim, Khaled Elmasry, +7 authors Mohamed Al-Shabrawey  Investigativeophthalmology & visual science 2018

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Alantolactoneplays neuroprotective roles in traumatic brain injury in rats viaanti-inflammatory, anti-oxidative and anti-apoptosis pathways.Xun Wang, Yu‐Long Lan, Jin‐Shan Xing, Xiao-Qiang Lan, Li-tao Wang, Bo Zhang American journal of translationalresearch   2018

Traumatic brain injury (TBI) is a common diseaseassociated with a high rate of morbidity and mortality. Secondary brain injuryfollowing TBI triggers pathological, physiological, and biological… (More)

 

Selectiveactivation of cannabinoid receptor-2 reducesneuroinflammation after traumaticbrain injury via alternative macrophagepolarization.   Molly R BraunZenab T Khan, +9 authors Kumar Vaibhav Brain,behavior,and immunity 2018

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Adata-driven approach for evaluating multi-modal therapy intraumatic braininjury   J HaefeliAdam R. Ferguson, +8 authors Stephen M Massa  Scientificreports 2017

Combination therapies targeting multiplerecovery mechanisms havethe potential for additive or synergistic effects, butexperimental design andanalyses of multimodal therapeutic trials are… (More)

 

TheControlled CorticalImpact Model:Applications, Considerations for Researchers,and Future Directions  Nicole OsierC. Edward Dixon  Front.Neurol. 2016

Controlled corticalimpact(CCI) is a mechanical model oftraumatic brain injury (TBI) that was developednearly 30years ago with the goalof creating atesting platform to determine the… (More)

 

AnimalModels of Posttraumatic Seizures and Epilepsy.   Alexander V. GlushakovOlena Y. GlushakovaSylvain DoréPaul R. CarneyRonald L. Hayes  Methodsinmolecular biology  2016

Posttraumatic epilepsy (PTE) is one of themost common anddevastating complications of traumatic brain injury (TBI).Currently, theetiopathology and mechanisms of PTE are poorly understood and asa… (More)

 

Age-DependentEffects of Haptoglobin Deletion inNeurobehavioral and Anatomical OutcomesFollowing Traumatic Brain Injury  Alexander V. GlushakovRodrigo AriasEmanuela TolosanoSylvain Doré Front. Mol. Biosci. 2016

Cerebral hemorrhages are common features oftraumatic braininjury (TBI) and their presence is associated with chronicdisabilities. Recentclinical and experimental evidence suggests that… (More)

 

HippocampalDegeneration after Traumatic Brain Injury: Roleof the PGE2 EP1 Receptor  Alexander V. Glushakov, Jennifer M.Galvis,Samantha L. Solaski, Sylvain Doré 2016

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This narrative provides a brief history ofexperimental animalmodel development for the study of traumatic brain injury.It draws upon arelatively rich history of early animal modeling that… (More)

 

Pharmacologicalinduction of the 70-kDa heat shock proteinprotects against brain injury.  Nacksung KimJ. Y. KimMidori A Yenari  Neuroscience 2015

The 70-kDa heat shock protein (HSP70) isknown to protect thebrain from injury through multiple mechanisms. Weinvestigated the effect ofpharmacological HSP70 induction in experimentaltraumatic… (More)

 

Focalmechanical injury induces astrogliosis in a 3D tissueengineered culture model   Ruth AngusAdina Teodora Michael-TitusJ. Craig Phillips  2015

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Brain injuries promote upregulation ofso-called proinflammatoryprostaglandins, notably prostaglandin E2 (PGE2),leading to overactivation of aclass of its cognate G-protein-coupledreceptors,… (More)

 

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